Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in Rats
نویسندگان
چکیده
In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg); however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.
منابع مشابه
GABAergic receptors in rostral ventrolateral medulla mediates the cardiovascular responses to activation of bed nucleus of the stria terminalis in the female rat
The bed nucleus of the stria terminalis (BST) is known to contain estrogen (E)- concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of GABA-A antagonist receptors, bicuculline methiodide (BMI), in the rostral ven...
متن کاملRole of adenosine receptors and protein phosphatases in the reversal of pentylenetetrazol-induced potentiation phenomenon by theta pulse stimulation in the CA1 region of rat hippocampal slices
The effect of theta pulse stimulation (TPS) on pentylenetetrazol (PTZ)-induced long-term potentiation of population spikes (PS) was studied in the hippocampal CA1 in vitro. A transient PTZ application produced a long-lasting enhancement of PS amplitude. A 3-min episode of TPS delivered at a higher intensity produced complete reversal of the PTZ potentiation when delivered during the last minute...
متن کاملGABAergic receptors in rostral ventrolateral medulla mediates the cardiovascular responses to activation of bed nucleus of the stria terminalis in the female rat
The bed nucleus of the stria terminalis (BST) is known to contain estrogen (E)- concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of GABA-A antagonist receptors, bicuculline methiodide (BMI), in the rostral ven...
متن کاملRole of adenosine receptors and protein phosphatases in the reversal of pentylenetetrazol-induced potentiation phenomenon by theta pulse stimulation in the CA1 region of rat hippocampal slices
The effect of theta pulse stimulation (TPS) on pentylenetetrazol (PTZ)-induced long-term potentiation of population spikes (PS) was studied in the hippocampal CA1 in vitro. A transient PTZ application produced a long-lasting enhancement of PS amplitude. A 3-min episode of TPS delivered at a higher intensity produced complete reversal of the PTZ potentiation when delivered during the last minute...
متن کاملCysteamine pretreatment reduces Mg2+-free medium-induced plasticity in the CA1 region of the rat hippocampal slices
Extracellular population responses are largely preferred for the study of long-term potentiation (LTP). The effect of Mg2+-free medium on changes in activity and plasticity of Schaffer collateral-CA1 pyramidal cell synapses was examined. Hippcampal slices from cysteamine-treated (200 mg/kg, s.c.) and saline-injected (1 ml/kg, s.c.) albino rats were perfused with ACSF. Population spikes (PS) wer...
متن کامل